INTERFERON-GAMMA REGULATES ANTIGEN-INDUCED EOSINOPHIL RECRUITMENT INTO THE MOUSE AIRWAYS BY INHIBITING THE INFILTRATION OF CD4+ T-CELLS

被引:269
作者
IWAMOTO, I
NAKAJIMA, H
ENDO, H
YOSHIDA, S
机构
[1] The Second Department of Internal Medicine, Chiba University School of Medicine, Chiba
关键词
D O I
10.1084/jem.177.2.573
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We have previously shown that antigen-induced eosinophil recruitment into the tissue of sensitized mice is mediated by CD4+ T cells and interleukin 5. To determine whether interferon gamma (IFN-gamma) regulates antigen-induced eosinophil recruitment into the tissue, we studied the effect of recombinant (r) murine IFN-gamma and of anti-IFN-gamma monoclonal antibody (mAb) on the eosinophil infiltration of the trachea induced by antigen inhalation in mice. The intraperitoneal administration of rIFN-gamma prevented antigen-induced eosinophil infiltration in the trachea of sensitized mice. The administration of rIFN-gamma also decreased antigen-induced CD4+ T cell but not CD8+ T cell infiltration in the trachea. On the other hand, pretreatment with anti-IFN-gamma mAb enhanced antigen-induced eosinophil and CD4+ T cell infiltration in the trachea. These results indicate that IFN-gamma regulates antigen-induced eosinophil recruitment into the tissue by inhibiting CD4+ T cell infiltration.
引用
收藏
页码:573 / 576
页数:4
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