DIAZABOROLIDINES, A NEW CLASS OF ENANTIOSELECTIVE ORGANOBORON CATALYTIC AGENTS

被引：15

作者：

FROELICH, O ^{[1
]}

BONIN, M ^{[1
]}

QUIRION, JC ^{[1
]}

HUSSON, HP ^{[1
]}

机构：

[1] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,CHIM THERAPEUT LAB,CNRS,URA 1310,F-75270 PARIS 06,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 11期

关键词：

ENANTIOSELECTIVE REDUCTION; DIAZABOROLIDINE; CHIRAL ALCOHOL; CATALYTIC REDUCTION; DIAMINE;

D O I：

10.1016/S0957-4166(00)80097-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Diazaborolidines 6 and 9, derived from 2-aminomethyl-piperidine, have been prepared in an optically pure form from 2-cyano-6-phenyl oxazolopiperidine 3. The best results for the asymmetric reduction of acetophenone (yield>95%, 72% ee) have been obtained with BH3.Me2S in the presence of 9a as a chiral catalyst.

引用

页码：2335 / 2338

页数：4

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