SYNTHESIS OF HUMAN ENDOTHELIN-1 BY REGIOSELECTIVE DISULFIDE FORMATION USING THE SILYL CHLORIDE-SULFOXIDE SYSTEM

被引：15

作者：

AKAJI, K ^{[1
]}

NISHIUCHI, H ^{[1
]}

KISO, Y ^{[1
]}

机构：

[1] KYOTO PHARMACEUT UNIV, DEPT MED CHEM, YAMASHIMA KU, KYOTO 607, JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 11期

关键词：

D O I：

10.1016/0040-4039(95)00172-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Human endothelin-1, a 21-amino acid peptide having two intramolecular disulfide bonds, has been synthesized by successive oxidation with iodine and methyltrichlorosilane-diphenylsulfoxide. Acetamidomethyl and tert-butyl groups were employed as the orthogonal thiol protecting groups, The indole ring of the C-terminal Trp residue was protected during the oxidation reaction with the formyl group that was introduced using the formic acid-HCl mixture after the peptide-chain construction.

引用

页码：1875 / 1878

页数：4

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