CARCINOGENICITY OF DI(N-NITROSO)-PERHYDROPYRIMIDINE (DNPP) AFTER INTRA-PERITONEAL APPLICATION TO RATS

被引：3

作者：

BERTRAM, B

HABS, M

WIESSLER, M

BRAUN, H

KRETZER, H

机构：

[1] Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg

来源：

CANCER LETTERS | 1979年 / 6卷 / 01期

关键词：

D O I：

10.1016/S0304-3835(79)80021-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Male Sprague-Dawley rats received 30 mg/kg body wt. (group I) or 15 mg/kg (group II) di(N-nitroso)-perhydropyrimidine (DNPP) by the intraperitoneal route once a week for life. The DNPP treatment significantly reduced the life expectancy in both groups. DNPP induced tumors of the esophagus (27% incidence in group I, 33% in group II) and possibly also of the liver (4% incidence in group I, 8% in group II). © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

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页码：57 / 60

页数：4

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