DELTAMYCINS, NEW MACROLIDE ANTIBIOTICS .3. CHEMICAL STRUCTURES

被引：5

作者：

SHIMAUCHI, Y ^{[1
]}

KUBO, K ^{[1
]}

OSUMI, K ^{[1
]}

OKAMURA, K ^{[1
]}

FUKAGAWA, Y ^{[1
]}

ISHIKURA, T ^{[1
]}

机构：

[1] PANLABS INC,FAYETTEVILLE,NY

来源：

JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 09期

关键词：

D O I：

10.7164/antibiotics.32.878

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of deltamycins A1, A2, A3 and A4 belonging to the basic macrolide family of antibiotics were determined mainly from their spectral properties. Deltamycin A4 was identified as carbomycin A having an isovaleryl group on the mycarose moiety of the moiecule. Deltamycin A1, A2 and A3 possess similarities to the structure of deltamycin A4, but they have acetyl, propionyl and n-butyryl group, respectively, in the place of isovaleryl group of deltamycin A4. These structures were confirmed by chemical synthesis from deltamycin X (4“-O-deacyldeltamycin) and the corresponding acyl chlorides. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：878 / 884

页数：7

共 6 条

[1]

OKAMURA K, 1977, J FERMENT TECHNOL, V55, P347

[2] C-13 NUCLEAR MAGNETIC-RESONANCE OF NATURAL AND RELATED PRODUCTS .20. C-13 NUCLEAR MAGNETIC-RESONANCE SPECTRAL ANALYSIS OF 16-MEMBERED MACROLIDE ANTIBIOTICS [J].