STABILITY OF FLUORENYLMETHOXYCARBONYLAMINO GROUPS IN PEPTIDE-SYNTHESIS - CLEAVAGE BY HYDROGENOLYSIS AND BY DIPOLAR APROTIC-SOLVENTS

被引：53

作者：

ATHERTON, E

BURY, C

SHEPPARD, RC

WILLIAMS, BJ

机构：

[1] MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road

来源：

TETRAHEDRON LETTERS | 1979年 / 32期

关键词：

D O I：

10.1016/S0040-4039(00)71007-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Fluorenylmethoxycarbonyl derivatives of amines are unexpectedly cleaved by catalytic hydrogenation with t 1 2 3-33 h. under various conditions. They are also cleaved on standing in the solvents dimethylformamide, dimethylacetamine, and N-methylpyrrolidone, but much more slowly. © 1979.

引用

页码：3041 / 3042

页数：2

共 9 条

[1] MILD PROCEDURE FOR SOLID-PHASE PEPTIDE-SYNTHESIS - USE OF "FLUORENYLMETHOXYCARBONYLAMINO-ACIDS [J].