IMPAIRED GROWTH IN HYPERKINETIC-CHILDREN RECEIVING PEMOLINE

被引:14
作者
DICKINSON, LC
LEE, J
RINGDAHL, IC
SCHEDEWIE, HK
KILGORE, BS
ELDERS, MJ
机构
[1] UNIV ARKANSAS MED SCI, DEPT PEDIAT, LITTLE ROCK, AR 72201 USA
[2] UNIV ARKANSAS MED SCI, DEPT PSYCHIAT, LITTLE ROCK, AR 72201 USA
关键词
D O I
10.1016/S0022-3476(79)80006-2
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Decreased longitudinal growth was observed in 24 hyperkinetic children receiving pemoline therapy. Mean height velocity was 3.67 .+-. 0.25 cm/yr during therapy but 5.35 .+-. 0.42 cm/yr after treatment had been discontinued (P < 0.01). There appeared to be an inverse relationship between growth velocity and drug dosage. All patients receiving less than the median dose of 3.72 mg/kg grew 4 cm/yr or more, while 7 of 12 patients receiving more than this dose grew at a slower rate. Body weight, basal and stimulated growth hormone values, and plasma somatomedin concentrations were not significantly altered by pemoline treatment, suggesting that this drug may have a direct effect on cartilage metabolism.
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收藏
页码:538 / 541
页数:4
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