CLINICAL RELEVANCE OF OPIATE RECEPTOR AND OPIOID PEPTIDE RESEARCH

被引:21
作者
SNYDER, SH [1 ]
机构
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205
关键词
D O I
10.1038/279013a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Numerous pharmaceutical concerns have developed enkephalin analogues for possible therapeutic uses, hoping that derivatives of such a natural substance might be non-addicting. One controlled study suggests beneficial effects in schizophrenia of an opioid-related peptide which has no opiate activity. [Des-Tyr1]-γ-endorphin comprises amino acids 62-77 of the pituitary peptide, β-lipotropin. The absence of an N-terminal tyrosine abolishes affinity for opiate receptors. On the basis of its behavioural effects in rats [des-Tyr1]-γ-endorphin was administered to chronic schizophrenics. In a double-blind placebo-controlled crossover design the peptide in daily doses of only mg dramatically alleviated schizophrenic symptoms.
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页码:13 / 14
页数:2
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