SYNTHESIS AND STRUCTURE DETERMINATION OF FR109615, A NEW ANTIFUNGAL ANTIBIOTIC

被引：66

作者：

KAWABATA, K ^{[1
]}

INAMOTO, Y ^{[1
]}

SAKANE, K ^{[1
]}

IWAMOTO, T ^{[1
]}

HASHIMOTO, S ^{[1
]}

机构：

[1] FUJISAWA PHARMACEUT CO LTD,EXPLORATORY RES LABS,TSUKUBA,IBARAKI 30026,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 05期

关键词：

D O I：

10.7164/antibiotics.43.513

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structure of FR109615, a new antifungal antibiotic, was determined to be (1R,2S)-2-aminocyclopentane-l-carboxylic acid ((-)-cis-2-ACPC: 8a) by X-ray analysis. (-)-cis-2-ACPC (8a) was also synthesized via optical resolution of 3a and 3b derived from (±)-cis-2-ACPC hydrochloride (1). 8a showed potent antifungal activity, while its antipode (+)-cis-2-ACPC (8b) had no activity. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：513 / 518

页数：6

共 5 条

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