Tyrosine Hydroxylase Maps to the Short Arm of Chromosome 11 Proximal to the Insulin and HRAS1 Loci

被引：19

作者：

Xue, F. ^{[1
]}

Kidd, J. R. ^{[1
]}

Pakstis, A. J. ^{[1
]}

Castiglione, C. M. ^{[1
]}

Mallet, J. ^{[2
]}

Kidd, K. K. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Human Genet, New Haven, CT 06510 USA

[2] CNRS, Neurobiol Cellulaire & Mol Lab, F-91190 Gif Sur Yvette, France

来源：

GENOMICS | 1988年 / 2卷 / 04期

关键词：

D O I：

10.1016/0888-7543(88)90016-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and a candidate gene for manic-depressive illness. The TH locus was typed for a BglII RFLP using a cDNA clone Ty7 in four large kindreds. Pairwise analyses and multipoint analyses were carried out to map the TH locus more precisely in the region of the linked markers: D11S12, INS, and HRAS1 on 11p. Results confirm the close linkage between TH with these previously mapped markers and support a most likely ordering which places TH on the side of INS where the centromere lies. (C) 1988 Academic Press, Inc.

引用

页码：288 / 293

页数：6

共 30 条

[1] BARKER D, 1984, AM J HUM GENET, V36, P1159
[2] POLYMORPHIC DNA REGION ADJACENT TO THE 5'-END OF THE HUMAN INSULIN GENE
BELL, GI
KARAM, JH
RUTTER, WJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09): : 5759 - 5763
[3] BUNNEY WE, 1965, ARCH GEN PSYCHIAT, V13, P483
[4] LOCALIZATION OF THE HUMAN TYROSINE-HYDROXYLASE GENE TO 11P15 - GENE DUPLICATION AND EVOLUTION OF METABOLIC PATHWAYS
CRAIG, SP
BUCKLE, VJ
LAMOUROUX, A
MALLET, J
CRAIG, I
[J]. CYTOGENETICS AND CELL GENETICS, 1986, 42 (1-2): : 29 - 32
[5] BIPOLAR AFFECTIVE-DISORDERS LINKED TO DNA MARKERS ON CHROMOSOME-11
EGELAND, JA
GERHARD, DS
PAULS, DL
SUSSEX, JN
KIDD, KK
ALLEN, CR
HOSTETTER, AM
HOUSMAN, DE
[J]. NATURE, 1987, 325 (6107) : 783 - 787
[6] A SINGLE HUMAN-GENE ENCODING MULTIPLE TYROSINE HYDROXYLASES WITH DIFFERENT PREDICTED FUNCTIONAL-CHARACTERISTICS
GRIMA, B
LAMOUROUX, A
BONI, C
JULIEN, JF
JAVOYAGID, F
MALLET, J
[J]. NATURE, 1987, 326 (6114) : 707 - 711
[7] KIDD J R, 1985, American Journal of Human Genetics, V37, pA161
[8] KIDD K. K., 1987, NEW DIRECTIONSIN AFF
[9] KIDD KK, 1984, AM J PSYCHIAT, V141, P1042
[10] KRAMER PL, 1986, GENET EPIDEMIOL, P153

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