SUBPICOMOLAR AMOUNTS OF NPY(13-36) INJECTED INTO THE NUCLEUS-TRACTUS-SOLITARIUS OF THE RAT COUNTERACT THE CARDIOVASCULAR-RESPONSES TO L-GLUTAMATE

被引:30
作者
NARVAEZ, JA [1 ]
AGUIRRE, JA [1 ]
FUXE, K [1 ]
机构
[1] KAROLINSKA INST, DEPT HISTOL & NEUROBIOL, S-10401 STOCKHOLM 60, SWEDEN
关键词
NEUROPEPTIDE-Y(13-36); NPY-Y2-RECEPTOR; L-GLUTAMATE; MICROINJECTION; BARORECEPTOR; CARDIOVASCULAR; RESPIRATION; RAT; BRAIN;
D O I
10.1016/0304-3940(93)90016-E
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of NPY(13-36) on cardiorespiratory responses elicited by microinjections of L-glutamate into the nucleus tractus solitarius (NTS) have been studied in anaesthetized (alpha-chloralose + urethane) Sprague-Dawley rats. NPY(13-36) in doses ranging from 50 to 500 fmol produces a significant increase in mean arterial pressure (MAP) without significant effects on heart rate (HR) and respiratory rate (RR). The ED50 dose (100 fmol) of NPY(13-36) counteracts significantly the decrease in MAP and HR elicited by L-glutamate (1500 pmol) microinjected into NTS. Similar results are obtained using a threshold dose of the peptide (50 fmol) and an ED50 dose Of L-glutamate (300 pmol). These results indicate that the Y2 receptors in NTS can mediate vasopressor responses to femtomolar amounts of NPY(13-36) and counteract cardiovascular responses to L-glutamate.
引用
收藏
页码:182 / 186
页数:5
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