CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF A TRIMERIC FORM OF HUMAN MANNOSE-BINDING PROTEIN

A trimeric form of the carbohydrate recognition domain of human mannose binding protein has been crystallized in two different forms. The first form crystallizes with symmetry consistent with space group P2(1)2(1)2(1) and a = 61 Angstrom; b = 144 Angstrom; c = 107 Angstrom with presumably two trimers in the asymmetric unit. The second form crystallizes with symmetry consistent with space group P321 and a = b = 77 Angstrom; c = 58 Angstrom and one monomer per asymmetric unit. The molecular and crystallographic S-folds must be coincident in this crystal form