ASYMMETRIC-SYNTHESIS OF ALPHA-KETO BETA-LACTAMS VIA [2+2] CYCLOADDITION REACTION - A CONCISE APPROACH TO OPTICALLY-ACTIVE ALPHA-HYDROXY BETA-LACTAMS AND BETA-ALKYL(ARYL)ISOSERINES

被引：30

作者：

PALOMO, C

AIZPURUA, JM

MIRANDA, JI

MIELGO, A

ODRIOZOLA, JM

机构：

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(00)73743-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cycloaddition reaction of the Evans-Sjogren ketenes to imines, followed by alpha-hydroxylation of the resulting cycloadducts provides an efficient general asymmetric synthesis of alpha-keto beta-lactams and derivatives.

引用

页码：6325 / 6328

页数：4

共 26 条

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