ICA1 ENCODING P69, A PROTEIN LINKED TO THE DEVELOPMENT OF TYPE-1 DIABETES, MAPS TO HUMAN-CHROMOSOME 7P22

被引：18

作者：

GAEDIGK, R

DUNCAN, AMV

MIYAZAKI, I

ROBINSON, BH

DOSCH, HM

机构：

[1] HOSP SICK CHILDREN,RES INST,DEPT PAEDIAT,TORONTO M5G 1X8,ON,CANADA

[2] HOSP SICK CHILDREN,RES INST,DEPT IMMUNOL,TORONTO M5G 1X8,ON,CANADA

[3] QUEENS UNIV,KINGSTON,ON,CANADA

[4] KINGSTON GEN HOSP,DEPT PATHOL,KINGSTON K7L 2V7,ON,CANADA

来源：

CYTOGENETICS AND CELL GENETICS | 1994年 / 66卷 / 04期

关键词：

D O I：

10.1159/000133711

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The development of type 1 (insulin dependent) diabetes mellitus (IDDM) requires a genetically susceptible host and exposure, early in life, to environmental trigger molecules that induce diabetic autoimmunity to insulin producing islet cells. We previously identified islet cell protein p69 as a candidate autoimmune target in IDDM. Here we describe a human genomic p69 fragment which allowed us to map the gene (ICA1) to chromosome 7p22.

引用

页码：274 / 276

页数：3

共 11 条

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