SUBMUCOSAL BLADDER NECK INJECTIONS OF GLUTARALDEHYDE CROSS-LINKED BOVINE COLLAGEN FOR THE TREATMENT OF URINARY-INCONTINENCE IN PATIENTS WITH THE EXSTROPHY/EPISPADIAS COMPLEX

被引：26

作者：

BENCHAIM, J

JEFFS, RD

PEPPAS, DS

GEARHART, JP

机构：

[1] JOHNS HOPKINS UNIV HOSP,JAMES BUCHANAN BRADY UROL INST,DEPT UROL,DIV PEDIAT UROL,BALTIMORE,MD 21287

[2] JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD 21218

来源：

JOURNAL OF UROLOGY | 1995年 / 154卷 / 02期

关键词：

COLLAGEN; BLADDER EXSTROPHY; BLADDER; EPISPADIAS; URINARY INCONTINENCE;

D O I：

10.1016/S0022-5347(01)67186-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

During the last 7 years 19 patients underwent 33 transurethral injections of glutaraldehyde cross-linked bovine collagen into the bladder neck for stress incontinence. Of the 15 patients 14 have classic bladder exstrophy, 3 have complete male epispadias and 2 have cloacal exstrophy. The procedure was performed after a Young-Dees-Leadbetter bladder neck reconstruction in 15 patients and before it in 4. Injections were repeated in 10 patients after a mean of 12 months. After a mean followup of 26 months (range 9 to 84) improvement of continence was noted in 10 of 19 patients (53%) of whom 4 have significant improvement. Of the 8 patients whose condition failed to improve after collagen injections 6 underwent additional successful surgery to achieve urinary continence. Of the 10 patients who underwent repeated collagen injections 9 (90%) had additional improvement. Although there were no complications related to the injected collagen itself, postoperative complications developed in 2 patients. Submucosal injection of collagen to the bladder neck is simple and safe, and has a reasonable success rate. Thus, it may be used to improve continence in patients with the exstrophy/epispadias complex who lack full control after appropriate reconstructive surgery.

引用

页码：862 / 864

页数：3

共 12 条

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