ROLE OF PROTEIN-BINDING AND PHARMACOKINETICS IN LACK OF CORRELATION BETWEEN INVITRO INHIBITION OF PG-SYNTHETASE AND INVIVO ANTIINFLAMMATORY ACTIVITY OF A HOMOLOGOUS SERIES OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS

被引：13

作者：

CESERANI, R ^{[1
]}

FERRARI, M ^{[1
]}

GOLDANIGA, G ^{[1
]}

MORO, E ^{[1
]}

BUTTINONI, A ^{[1
]}

机构：

[1] CARLO ERBA RES INST,MILAN,ITALY

来源：

LIFE SCIENCES | 1977年 / 21卷 / 02期

关键词：

D O I：

10.1016/0024-3205(77)90305-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：223 / 229

页数：7

共 25 条

[1]

BUTTINON.A, 1973, ARZNEIMITTELFORSCH, V23, P1100

[2]

COLLIER JG, 1971, LANCET, V2, P852

[3] EFFECTS OF ANTIINFLAMMATORY DRUGS ON PROSTAGLANDIN BIOSYNTHESIS [J].

FLOWER, R ;

VANE, JR ;

GRYGLEWS.R ;

HERBACZY.K .

NATURE-NEW BIOLOGY, 1972, 238 (82) :104-&

[4] QUANTITATIVE-DETERMINATION OF PROSTAGLANDINS AND MALONDIALDEHYDE FORMED BY ARACHIDONATE OXYGENASE (PROSTAGLANDIN SYNTHETASE) SYSTEM OF BOVINE SEMINAL VESICLE [J].

FLOWER, RJ ;

CUSHMAN, DW ;

CHEUNG, HS .

PROSTAGLANDINS, 1973, 4 (03) :325-341

[5]

FUCCELLA LM, 1975, CLIN PHARMACOL THER, V17, P277

[6] FATE OF ANALGESIC AND ANTIINFLAMMATORY DRUG K-4277 AFTER ORAL-ADMINISTRATION TO MAN [J].

FUCCELLA, LM ;

GOLDANIGA, GC ;

MORO, E ;

TAMASSIA, V ;

TOSOLINI, GP ;

VALZELLI, G .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1973, 6 (04) :256-260

[7]

GRYGLEWSKI R, IN PRESS

[8]

GRYGLEWSKI RJ, 1976, ADV PROSTAG THROMB R, V1, P117

[9]

Ham E.A., 1972, PROSTAGLANDINS CELLU, P345

[10] INHIBITION OF PROSTAGLANDIN SYNTHESIS IN MAN [J].

HAMBERG, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1972, 49 (03) :720-&

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