BARORECEPTOR ACTIVATION REDUCES REACTIVITY TO NOXIOUS-STIMULATION - IMPLICATIONS FOR HYPERTENSION

被引：242

作者：

DWORKIN, BR ^{[1
]}

FILEWICH, RJ ^{[1
]}

MILLER, NE ^{[1
]}

CRAIGMYLE, N ^{[1
]}

PICKERING, TG ^{[1
]}

机构：

[1] CORNELL UNIV, MED CTR,NEW YORK HOSP,CTR CARDIOVASC HYPERTENS, NEW YORK, NY 10021 USA

来源：

SCIENCE | 1979年 / 205卷 / 4412期

关键词：

D O I：

10.1126/science.472749

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The hypothesis was tested that an acute rise of blood pressure may reduce reactivity to noxious stimuli through a baroreceptor-mediated reduction of cerebral arousal. When blood pressure was raised by an infusion of phenylephrine, rats showed less running to terminate or avoid noxious stimuli than during saline infusions. This effect was not seen in rats with denervated baroreceptors. The results suggest that a rise of blood pressure could have motivational consequences significant for human hypertension. Copyright © 1979 AAAS.

引用

页码：1299 / 1301

页数：3

共 32 条

[1] ADAM G, 1963, ACTA PHYSIOL HUNG, V23, P339
[2] Bartorelli C, 1960, ARCH ITAL BIOL, V98, P308
[3] BEHAVIORAL INDUCTION OF ARTERIAL HYPERTENSION AND ITS REVERSAL
BENSON, H
HERD, JA
MORSE, WH
KELLEHER, RT
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1969, 217 (01): : 30 - &
[4] BONVALLET M, 1953, CR SOC BIOL, V147, P1166
[5] BONVALLET M, 1953, CR SOC BIOL, V147, P1168
[6] RESPONSE STRENGTH AS A FUNCTION OF DRIVE LEVEL AND AMOUNT OF DRIVE REDUCTION
CAMPBELL, BA
KRAELING, D
[J]. JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 1953, 45 (02): : 97 - 101
[7] IS HIGH BLOOD PRESSURE A PSYCHOSOMATIC DISORDER - CRITICAL REVIEW OF EVIDENCE
DAVIES, MH
[J]. JOURNAL OF CHRONIC DISEASES, 1971, 24 (04): : 239 - +
[8] DWORKIN BR, AM J PHYSIOL
[9] Carotid sinus syncope and its bearing on the mechanism of the unconscious state and convulsions - A study of 32 additional cases
Ferris, EB
Capps, RB
Weiss, S
[J]. MEDICINE, 1935, 14 (04) : 377 - 456
[10] GENETIC PREDISPOSITION AND STRESS-INDUCED HYPERTENSION
FRIEDMAN, R
IWAI, J
[J]. SCIENCE, 1976, 193 (4248) : 161 - 162

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