CIRCADIAN-RHYTHMS AND DRUG DELIVERY

被引：92

作者：

LEMMER, B

机构：

[1] Zentrum der Pharmakologie, J.W. Goethe-Universität, Frankfurt

来源：

JOURNAL OF CONTROLLED RELEASE | 1991年 / 16卷 / 1-2期

关键词：

CIRCADIAN RHYTHMS; CHRONOPHARMACOKINETICS; CHRONOPHARMACODYNAMICS; ANTIASTHMATICS; CARDIOVASCULAR ACTIVE DRUGS;

D O I：

10.1016/0168-3659(91)90031-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Circadian rhythms in the functions of the body are well established, e.g. in cardiovascular (blood pressure, heart rate, blood flow, etc.), pulmonary, hepatic and renal functions. Also the symptoms and onset of disease are not randomly distributed within the 24 hours of a day (e.g. coronary infarction, angina pectoris and asthmatic attacks). It is, therefore, not surprising that also the effects and/or pharmacokinetics of drugs can display significant daily variations. Recent data on the chronopharmacodynamics and chronopharmacokinetics of H-2-blockers, anti-asthmatics (theophylline, terbutaline), cardiovascular active drugs (propranolol, organic nitrates, nifedipine) are described as representative examples. These data demonstrate that biological rhythms have to be taken into account when evaluating drug delivery systems, galenic formulations and pharmacokinetics as a basis for drug treatment.

引用

页码：63 / 74

页数：12

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