ANTIVIRAL ACTIVITY OF SOME NATURAL AND SYNTHETIC SUGAR ANALOGS

被引：9

作者：

HUANG, R

DIETSCH, E

LOCKHOFF, O

SCHULLER, M

REUTTER, W

机构：

[1] FREE UNIV BERLIN,INST MOLEK BIOL & BIOCHEM,ARNIMALLEE 22,W-1000 BERLIN 33,GERMANY

[2] BAYER AG,W-5600 WUPPERTAL 1,GERMANY

来源：

FEBS LETTERS | 1991年 / 291卷 / 02期

关键词：

SUGAR ANALOG; SYNTHETIC SUGAR; ANTIVIRAL ACTIVITY; HEMAGGLUTINATING TITER; INFLUENZA VIRUS;

D O I：

10.1016/0014-5793(91)81283-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of natural and synthetic sugar analogues have been tested for their antiviral activity, using an influenza virus strain as a model. Hemagglutinating titres (HA) and cytopathic effect (CPE) were surveyed to estimate the virus production. It was found that introduction of the benzyl group into these sugars generally causes them to become antivirally active. Substitution with methyl, acetyl, uridyl and thiocyanyl groups or derivatization with azido, isopropylidene and benzylidene groups were without effect. All sugars containing the 2-deoxy-2-acetamido group were inactive.

引用

页码：199 / 202

页数：4

共 12 条

[1] GLYCOSYLATION INHIBITORS BLOCK THE EXPRESSION OF LAV/HTLV-III(HIV) GLYCOPROTEINS
BLOUGH, HA
PAUWELS, R
DECLERCQ, E
COGNIAUX, J
SPRECHERGOLDBERGER, S
THIRY, L
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 141 (01) : 33 - 38
[2] INTERFERENCE WITH GLYCOSYLATION OF GLYCOPROTEINS - INHIBITION OF FORMATION OF LIPID-LINKED OLIGOSACCHARIDES INVIVO
DATEMA, R
SCHWARZ, RT
[J]. BIOCHEMICAL JOURNAL, 1979, 184 (01) : 113 - 123
[3] INHIBITION OF HIV REPLICATION BY AMINO-SUGAR DERIVATIVES
FLEET, GWJ
KARPAS, A
DWEK, RA
FELLOWS, LE
TYMS, AS
PETURSSON, S
NAMGOONG, SK
RAMSDEN, NG
SMITH, PW
SON, JC
WILSON, F
WITTY, DR
JACOB, GS
RADEMACHER, TW
[J]. FEBS LETTERS, 1988, 237 (1-2) : 128 - 132
[4] INHIBITORS OF OLIGOSACCHARIDE PROCESSING
FUHRMANN, U
BAUSE, E
PLOEGH, H
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 825 (02) : 95 - 110
[5] INTERFERENCE WITH HIV-INDUCED SYNCYTIUM FORMATION AND VIRAL INFECTIVITY BY INHIBITORS OF TRIMMING GLUCOSIDASE
GRUTERS, RA
NEEFJES, JJ
TERSMETTE, M
DEGOEDE, REY
TULP, A
HUISMAN, HG
MIEDEMA, F
PLOEGH, HL
[J]. NATURE, 1987, 330 (6143) : 74 - 77
[6] EFFECT OF IMPAIRED GLYCOSYLATION ON BIOSYNTHESIS OF SEMLIKI FOREST VIRUS GLYCOPROTEINS
KALUZA, G
[J]. JOURNAL OF VIROLOGY, 1975, 16 (03) : 602 - 612
[7] EFFECT OF 2-DEOXY-D-GLUCOSE ON MULTIPLICATION OF SEMLIKI FOREST VIRUS AND REVERSAL OF BLOCK BY MANNOSE
KALUZA, G
SCHMIDT, MFG
SCHOLTISSEK, C
[J]. VIROLOGY, 1973, 54 (01) : 179 - 189
[8] INHIBITION OF MULTIPLICATION OF ENVELOPED RNA-VIRUSES BY GLUCOSAMINE AND 2-DEOXY-D-GLUCOSE
KALUZA, G
ROTT, R
SCHOLTISSEK, C
[J]. JOURNAL OF GENERAL VIROLOGY, 1972, 14 (MAR) : 251 - +
[9] CASTANOSPERMINE INHIBITS THE PROCESSING OF THE OLIGOSACCHARIDE PORTION OF THE INFLUENZA VIRAL HEMAGGLUTININ
PAN, YT
HORI, H
SAUL, R
SANFORD, BA
MOLYNEUX, RJ
ELBEIN, AD
[J]. BIOCHEMISTRY, 1983, 22 (16) : 3975 - 3984
[10] CASTANOSPERMINE INHIBITS ALPHA-GLUCOSIDASE ACTIVITIES AND ALTERS GLYCOGEN DISTRIBUTION IN ANIMALS
SAUL, R
GHIDONI, JJ
MOLYNEUX, RJ
ELBEIN, AD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (01) : 93 - 97

← 1 2 →