IMMUNE-RESPONSE TO ENDOTOXIN ISOLATED FROM BACTEROIDES-FRAGILIS IN THE PREGNANT GUINEA-PIG

被引：1

作者：

BECKMANN, I ^{[1
]}

MEISELMIKOLAJCZYK, F ^{[1
]}

LESZCZYNSKI, P ^{[1
]}

WALLENBURG, HCS ^{[1
]}

机构：

[1] MED ACAD WARSAW,INST BIOSTRUCT,DEPT BACTERIOL & IMMUNOL,PL-02032 WARSAW,POLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1990年 / 93卷 / 2-3期

关键词：

D O I：

10.1159/000235305

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The humoral immune response to endotoxin isolated from Bacteroides fragilis was analyzed in the pregnant guinea pig by means of passive hemagglutination, passive hemolysis, a modified Coombs test, and by crossed immunoelectrophoresis. Pregnant animals were immunized with endotoxin on day 30 of gestation, and antibodies were determined on day 61 in maternal and fetal sera, and in amniotic fluid. The IgG and IgM responses in maternal sera were of the same magnitude as in sera of nonpregnant animals. Fetal sera contained IgG and sometimes IgM, and a higher percentage of incomplete antibodies against endotoxin than maternal sera. Low-titer anti-endotoxin antibodies, partially sensitive to dithiothreitol, were found in amniotic fluid. A statistically significant reduction in the growth of fetuses from endotoxin-immunized females was observed.

引用

页码：222 / 226

页数：5

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