HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 INFECTION AND FUSION OF CD4-NEGATIVE HUMAN CELL-LINES - INDUCTION AND ENHANCEMENT BY SOLUBLE CD4

被引：165

作者：

CLAPHAM, PR ^{[1
]}

MCKNIGHT, A ^{[1
]}

WEISS, RA ^{[1
]}

机构：

[1] INST CANC RES,CHESTER BEATTY LABS,237 FULHAM RD,LONDON SW3 6JB,ENGLAND

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 06期

关键词：

D O I：

10.1128/JVI.66.6.3531-3537.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe human immunodeficiency type 2 (HIV-2) strains which induce cell-to-cell fusion and infect certain CD4- human cell lines. Soluble CD4 (sCD4) induces or enhances fusion by most HIV-2 strains tested. Soluble CD4-immunoglobulin G chimeras and conjugates of sCD4 and antibody to the third domain of CD4 block HIV-2 fusion of CD4- cells. We conclude that HIV-2 can enter CD4- cells via an alternative cell surface receptor to CD4. While some strains entered efficiently, others retained a dependency on an interaction with sCD4 to initiate changes in the virion envelope required for membrane fusion.

引用

页码：3531 / 3537

页数：7

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