KINETIC RESOLUTION STRATEGIES .2. ENHANCED ENANTIOMERIC EXCESSES AND YIELDS FOR THE FASTER REACTING ENANTIOMER IN LIPASE-MEDIATED KINETIC RESOLUTIONS

被引：38

作者：

BROWN, SM

DAVIES, SG

DESOUSA, JAA

机构：

[1] DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND

[2] ZENECA FCMO,N ENGLAND WORKS,HUDDERSFIELD HD2 1FF,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)80119-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A strategy for the preparation of the faster reacting (R)-enantiomer of 1-(4-methoxyphenyl)ethanol with 95% ee in 37% overall yield via a double kinetic resolution strategy involving Pseudomonas fluorescens lipase mediated sequential acetylation and hydrolysis is described.

引用

收藏

页码：813 / 822

页数：10

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