PHOSPHORYL TRANSFER IN FLP RECOMBINATION - A TEMPLATE FOR STRAND TRANSFER MECHANISMS

被引：35

作者：

JAYARAM, M

机构：

[1] M. Jayaram is at the Department of Microbiology, University of Texas at Austin, Austin

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0968-0004(94)90039-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The basic chemistry involved in DNA recombination, RNA splicing and DNA transposition is a phosphoryl transfer reaction. This review is an attempt to provoke a unified thinking on the reaction mechanisms in these nucleic acid transactions. Some of the recent results with the Flp site-specific recombinase that reveal how the chemical reactivity for recombination is derived from cooperative protein-subunit interactions on the DNA substrate are discussed. At least some of the features of Flp reaction are likely to have global implications in other DNA and RNA strand-transfer systems.

引用

页码：78 / 82

页数：5

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