DNA LOOP REPAIR BY HUMAN CELL-EXTRACTS

被引：128

作者：

UMAR, A ^{[1
]}

BOYER, JC ^{[1
]}

KUNKEL, TA ^{[1
]}

机构：

[1] NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709

来源：

SCIENCE | 1994年 / 266卷 / 5186期

关键词：

D O I：

10.1126/science.7973637

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An activity in human cell extracts is described tt lat repairs DNA with loops of five or more unpaired bases. Repair is strand-specific and is directed by a nick located 5' or 3' to the loop. This repair is observed in a colorectal cancer cell line that is devoid of a wild-type hMLH1 gene and is deficient in repair of mismatches. However, a cell line with deletions in both hMSH2 alleles is deficient in repair of both loops and mismatches. Defects in loop repair may be relevant to the repetitive-sequence instability observed in cancers and other hereditary diseases.

引用

页码：814 / 816

页数：3

共 44 条

[1] CLUES TO THE PATHOGENESIS OF FAMILIAL COLORECTAL-CANCER
AALTONEN, LA
PELTOMAKI, P
LEACH, FS
SISTONEN, P
PYLKKANEN, L
MECKLIN, JP
JARVINEN, H
POWELL, SM
JEN, J
HAMILTON, SR
PETERSEN, GM
KINZLER, KW
VOGELSTEIN, B
DELACHAPELLE, A
[J]. SCIENCE, 1993, 260 (5109) : 812 - 816
[2] ALLTONEN LA, 1994, CANCER RES, V54, P1645
[3] SURVEY OF HUMAN AND RAT MICROSATELLITES
BECKMANN, JS
WEBER, JL
[J]. GENOMICS, 1992, 12 (04) : 627 - 631
[4] MUTATION IN THE DNA MISMATCH REPAIR GENE HOMOLOG HMLH1 IS ASSOCIATED WITH HEREDITARY NONPOLYPOSIS COLON-CANCER
BRONNER, CE
BAKER, SM
MORRISON, PT
WARREN, G
SMITH, LG
LESCOE, MK
KANE, M
EARABINO, C
LIPFORD, J
LINDBLOM, A
TANNERGARD, P
BOLLAG, RJ
GODWIN, AR
WARD, DC
NORDENSKJOLD, M
FISHEL, R
KOLODNER, R
LISKAY, RM
[J]. NATURE, 1994, 368 (6468) : 258 - 261
[5] REPAIR OF HETERODUPLEX DNA-MOLECULES WITH MULTIBASE LOOPS IN ESCHERICHIA-COLI
CARRAWAY, M
MARINUS, MG
[J]. JOURNAL OF BACTERIOLOGY, 1993, 175 (13) : 3972 - 3980
[6] DAWE CJ, 1964, JNCI-J NATL CANCER I, V33, P441
[7] DEXTER DL, 1979, CANCER RES, V39, P1020
[8] ENGEL LW, 1978, CANCER RES, V38, P3352
[9] FANG WH, 1993, J BIOL CHEM, V268, P11838
[10] FISHEL R, 1993, CELL, V75, P1075

← 1 2 3 4 5 →