LIPOXYGENASE INHIBITORS .4. SYNTHESIS AND CYCLIZATION REACTIONS OF OPEN-CHAIN N-1-ARYL-SUBSTITUTED AMIDRAZONES

被引：21

作者：

FROHBERG, P ^{[1
]}

KUPFER, C ^{[1
]}

STENGER, P ^{[1
]}

BAUMEISTER, U ^{[1
]}

NUHN, P ^{[1
]}

机构：

[1] UNIV HALLE WITTENBERG,INST PHYS CHEM,D-06108 HALLE,GERMANY

来源：

ARCHIV DER PHARMAZIE | 1995年 / 328卷 / 06期

关键词：

D O I：

10.1002/ardp.19953280607

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

alpha-Carbonyl carboxylic acid arylhydrazonochlorides obtained by Japp-Klingemann reaction are the starting substances for the synthesis of alpha-carbonyl carboxylic acid arylhydrazonoamides, -esters and -thioesters. The inhibiting activity of these compounds against 15- and 5-lipoxygenase is described. Reactions of derivatives of amidrazones with formaldehyde give triazole, triazoline and unexpected benzotriazepine derivatives.

引用

页码：505 / 516

页数：12

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