HUMAN GLIAL-CELL LINE-DERIVED NEUROTROPHIC FACTOR (GDNF) MAPS TO CHROMOSOME-5

被引：12

作者：

BERMINGHAM, N

HILLERMANN, R

GILMOUR, F

MARTIN, JE

FISHER, EMC

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND

[2] LONDON HOSP,COLL MED,DEPT HISTOPATHOL,LONDON E1 1BB,ENGLAND

来源：

HUMAN GENETICS | 1995年 / 96卷 / 06期

关键词：

D O I：

10.1007/BF00210297

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Neurotrophic factors are essential neurone survival promoting molecules that are often secreted and that bind to neuronal cell surface receptors. Glial cell line-derived neurotrophic factor, GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures. We have mapped the gene encoding GDNF by two independent methods: using a cell hybrid panel and by fluorescent in situ hybridisation. We find GDNF lies on the short arm of human chromosome 5, at 5p13.1-p13.3.

引用

页码：671 / 673

页数：3

共 11 条

[1] A 3.5 GENOME EQUIVALENT MULTIACCESS YAC LIBRARY - CONSTRUCTION, CHARACTERIZATION, SCREENING AND STORAGE [J].

ANAND, R ;

RILEY, JH ;

BUTLER, R ;

SMITH, JC ;

MARKHAM, AF .

NUCLEIC ACIDS RESEARCH, 1990, 18 (08) :1951-1956

[2] PHYSICAL AND GENETIC-MAPPING OF A HUMAN APICAL EPITHELIAL NA+/H+ EXCHANGER (NHE3) ISOFORM TO CHROMOSOME-5P15.3 [J].

BRANT, SR ;

BERNSTEIN, M ;

WASMUTH, JJ ;

TAYLOR, EW ;

MCPHERSON, JD ;

LI, X ;

WALKER, S ;

POUYSSEGUR, J ;

DONOWITZ, M ;

TSE, CM ;

JABS, EW .

GENOMICS, 1993, 15 (03) :668-672

[3] LINKAGE OF THE LEUS, EMTB, AND CHR GENES ON CHROMOSOME-5 IN HUMANS AND EXPRESSION OF HUMAN GENES ENCODING PROTEIN SYNTHETIC COMPONENTS IN HUMAN CHINESE-HAMSTER HYBRIDS [J].

DANA, S ;

WASMUTH, JJ .

SOMATIC CELL GENETICS, 1982, 8 (02) :245-264

[4] GDNF - A POTENT SURVIVAL FACTOR FOR MOTONEURONS PRESENT IN PERIPHERAL-NERVE AND MUSCLE [J].

HENDERSON, CE ;

PHILLIPS, HS ;

POLLOCK, RA ;

DAVIES, AM ;

LEMEULLE, C ;

ARMANINI, M ;

SIMPSON, LC ;

MOFFET, B ;

VANDLEN, RA ;

KOLIATSOS, VE ;

ROSENTHAL, A .

SCIENCE, 1994, 266 (5187) :1062-1064

[5] MAPPING THE GENE THAT ENCODES PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C-GAMMA-2 IN THE HUMAN AND THE MOUSE [J].

HERNANDEZ, D ;

EGAN, SE ;

YULUG, IG ;

FISHER, EMC .

GENOMICS, 1994, 23 (02) :504-507

[6] CLINICAL PHENOTYPE AND MOLECULAR ANALYSIS OF A 3-GENERATION FAMILY WITH AN INTERSTITIAL DELETION OF THE SHORT ARM OF CHROMOSOME-5 [J].

KEPPEN, LD ;

GOLLIN, SM ;

EDWARDS, D ;

SAWYER, J ;

WILSON, W ;

OVERHAUSER, J .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1992, 44 (03) :356-360

[7] DUPLICATION (5P13-]PTER) - PRENATAL-DIAGNOSIS AND REVIEW OF THE LITERATURE [J].

KHODR, GS ;

CADENA, G ;

LE, KL ;

KAGANHALLET, KS .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1982, 12 (01) :43-49

[8] GDNF - A GLIAL-CELL LINE DERIVED NEUROTROPHIC FACTOR FOR MIDBRAIN DOPAMINERGIC-NEURONS [J].

LIN, LFH ;

DOHERTY, DH ;

LILE, JD ;

BEKTESH, S ;

COLLINS, F .

SCIENCE, 1993, 260 (5111) :1130-1132

[9]

PHELAN MC, 1988, AM J HUM GENET, V43, P511

[10] MAPPING GRB2, A SIGNAL-TRANSDUCTION GENE IN THE HUMAN AND THE MOUSE [J].

YULUG, IG ;

EGAN, SE ;

SEE, CG ;

FISHER, EMC .

GENOMICS, 1994, 22 (02) :313-318

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