SIGNIFICANCE OF SALICYLIC ACID SUBLIMATION IN STABILITY TESTING OF ASPIRIN-CONTAINING SOLIDS

被引：30

作者：

GORE, AY

NAIK, KB

KILDSIG, DO

PECK, GE

SMOLEN, VF

BANKER, GS

机构：

[1] Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmacal Sciences, Purdue University, Lafayette, Indiana

[2] Pharmaceutical Research Dept, Miles Laboratories, Elkhart, Indiana

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 11期

关键词：

Aspirin stability—salicylic acid sublimation; Salicylic acid sublimation—aspirin tablets; Temperature effect—aspirin tablets stability; UV spectrophotometry—analysis;

D O I：

10.1002/jps.2600571105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The salicylic acid content, formed from the decomposition of aspirin, was found to be an unreliable basis for judging the stability of aspirin tablets. Under conditions of accelerated stability testing, the loss of salicylic acid from the system by sublimation can incur appreciable errors in the direction of overestimating aspirin stability. Since aspirin was not detected to sublime under these same conditions, its residual content is an improved indication of its stability. A method for its simultaneous determination with salicylic acid is presented. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1850 / &

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