PRESYNAPTIC AND POSTSYNAPTIC LOCALIZATION OF CENTRAL MUSCARINIC RECEPTORS

被引：22

作者：

AGUILAR, JS

CRIADO, M

DEROBERTIS, E

机构：

[1] Instituto de Biología Celular, Facultad de Medicina, Universidad de Buenos Aires

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 57卷 / 2-3期

关键词：

!sup]14[!/sup]C-DMTC binding; !sup]3[!/sup]H-QNB binding; Receptor localization; Synaptic complexes; Synaptosomal membranes;

D O I：

10.1016/0014-2999(79)90369-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

3H-Quinuclidinyl benzylate and dimethyl 14C-d-tubocurarine were used to localize muscarinic and nicotinic receptors in synaptosomal membranes of the rat cerebral cortex. The results obtained, after the action of different concentrations of Triton X-100, suggest that, while nicotinic receptors are postsynaptic, the muscarinic ones are both pre- and postsynaptic. © 1979.

引用

页码：227 / 230

页数：4

共 10 条

[1]

AROSTAM RS, 1978, LIFE SCI, V23, P1377

[2] STEREOSPECIFIC BINDING AS A TOOL IN ATTEMPTS TO LOCALIZE AND ISOLATE MUSCARINIC RECEPTORS .2. BINDING OF (+)-BENZETIMIDE, (-)-BENZETIMIDE AND ATROPINE TO A FRACTION FROM BOVINE TRACHEAL SMOOTH-MUSCLE AND TO BOVINE CAUDATE-NUCLEUS [J].