ISOLATION AND STRUCTURE ELUCIDATION OF A NOVEL GRISEORHODIN

被引：40

作者：

STROSHANE, RM ^{[1
]}

CHAN, JA ^{[1
]}

RUBALCABA, EA ^{[1
]}

GARRETSON, AL ^{[1
]}

ASZALOS, AA ^{[1
]}

ROLLER, PP ^{[1
]}

机构：

[1] NCI, BETHESDA, MD 20014 USA

来源：

JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 03期

关键词：

D O I：

10.7164/antibiotics.32.197

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three antibiotics possessing cytotoxic properties were isolated from a strain of Streptomyces griseus (FCRC-57). One was found to be identical with griseorhodin A.2~6 A second, FCRC-57-U, was found to be identical to griseorhodin C7). FCRC-57-G is a new antibiotic structurally related to griseorhodins A and C, and is active against KB cells in vitro. The structure of this new antibiotic was determined using mass spectrometry, proton and carbon nuclear magnetic resonance spectroscopy and synthesis. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：197 / 204

页数：8

共 15 条

[1] STRUCTURE DETERMINATION OF PURPUROMYCIN, A NEW ANTIBIOTIC [J].