PHYSEAL RECONSTRUCTION USING TISSUE DONATED FROM EARLY POSTNATAL LIMBS IN A MURINE MODEL

被引:2
作者
CUNDY, PJ
JOFE, M
ZALESKE, DJ
EHRLICH, MG
MANKIN, HJ
机构
[1] MASSACHUSETTS GEN HOSP,DEPT ORTHOPAED,ACC 507,BOSTON,MA 02114
[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115
[3] ADELAIDE CHILDRENS HOSP INC,ADELAIDE,SA 5006,AUSTRALIA
关键词
PHYSIS; RECONSTRUCTION; TRANSPLANTATION; POSTNATAL TISSUE;
D O I
10.1002/jor.1100090307
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Physeal reconstruction was performed in a murine model by transplanting corresponding postnatal tissue from 4-day-old C57B mice to resection defects. The site of the reconstruction, the murine distal femoral epiphysis, is completely cartilaginous and avascular at this stage of development. The tissue transplanted into the defect was demonstrated to have high kinetic activity by its incorporation of titriated thymidine. The physeal reconstruction as performed restored only 25% of normal growth. While transplanting cell populations is feasible, the method will require a great deal of work before clinical application.
引用
收藏
页码:360 / 366
页数:7
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