DIFFERENT ACYLATION AND ACCUMULATION IN FREE FORM OF ARACHIDONIC-ACID OR ITS SODIUM-SALT IN HUMAN-PLATELETS

被引：4

作者：

CHAMBAZ, J ^{[1
]}

ROBERT, A ^{[1
]}

WOLF, C ^{[1
]}

BEREZIAT, G ^{[1
]}

POLONOVSKI, J ^{[1
]}

机构：

[1] FAC MED ST ANTOINE,HEMATOL LAB,F-75012 PARIS,FRANCE

来源：

THROMBOSIS RESEARCH | 1979年 / 15卷 / 5-6期

关键词：

D O I：

10.1016/0049-3848(79)90184-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Arachidonic acid uptake by platelets, studied by incubating platelet-rich plasma with increasing quantities of arachidonic acid, displays a maximal rate above 2.10-4 M plasma level. In free form, arachidonic acid is slightly accumulated by platelets while free linoleic acid accumulation increases proportionately to its plasma level above 3.10-4 M. Comparison of renewal rates of arachidonyl residues in main platelet lipids for arachidonic acid and for its sodium salt shows in the latter case a slower acylating process and a twice higher accumulation in free form thus a greater availability for thromboxane synthesis systems. This can explain why 0.5 mM arachidonate are sufficient to trigger aggregation while it isn't triggered by arachidonic acid below 1 mM plasma level. © 1979.

引用

页码：743 / 753

页数：11

共 22 条

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