INVIVO EFFECT OF PROTEASE INHIBITORS IN DENERVATION ATROPHY

被引：26

作者：

STRACHER, A ^{[1
]}

MCGOWAN, EB ^{[1
]}

HEDRYCH, A ^{[1
]}

SHAFIQ, SA ^{[1
]}

机构：

[1] SUNY DOWNSTATE MED CTR, DEPT NEUROL, BROOKLYN, NY 11203 USA

来源：

EXPERIMENTAL NEUROLOGY | 1979年 / 66卷 / 03期

关键词：

D O I：

10.1016/0014-4886(79)90206-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The protease inhibitors leupeptin and pepstatin were used in vivo to examine their effect on denervation-induced atrophy in chicken pectoralis muscle. Comparison of muscle weights, fiber diameters, and light meromyosin paracrystals in treated versus untreated animals indicated that these inhibitors had a significant effect in delaying denervation atrophy. The studies suggest that protease inhibitors may have potential therapeutic capability in a variety of neuromuscular degenerative disorders. © 1979.

引用

页码：611 / 618

页数：8

共 15 条

[1]

ADAMS RD, 1974, DISORDERS VOLUNTARY, P168

[2]

CHELMICKASCHORR EE, 1978, J NEUROPATHOL EXP NE, V37, P263

[3] THERAPEUTIC TRIALS IN MUSCULAR-DYSTROPHY .3. STUDIES OF MICROBIAL PROTEINASE-INHIBITORS IN MURINE DYSTROPHY [J].

ENOMOTO, A ;

BRADLEY, WG .

ARCHIVES OF NEUROLOGY, 1977, 34 (12) :771-773

[4]

GOLDBERG AL, 1977, PATHOGENESIS HUMAN M, P376

[5]

KALAMKAROVA MB, 1976, PHYSIOL BOHEMOSLOV, V25, P543

[6]

KAR NC, 1977, PATHOGENESIS HUMAN M, P387

[7] LEUPEPTIN, A PROTEASE INHIBITOR, DECREASES PROTEIN DEGRADATION IN NORMAL AND DISEASED MUSCLES [J].

LIBBY, P ;

GOLDBERG, AL .

SCIENCE, 1978, 199 (4328) :534-536

[8]

MARGRETH A, 1977, PATHOGENESIS HUMAN M, P161

[9] DELAYED DEGENERATION OF DYSTROPHIC AND NORMAL MUSCLE-CELL CULTURES TREATED WITH PEPSTATIN, LEUPEPTIN, AND ANTIPAIN [J].

MCGOWAN, EB ;

SHAFIQ, SA ;

STRACHER, A .

EXPERIMENTAL NEUROLOGY, 1976, 50 (03) :649-657

[10] LIGHT-MEROMYOSIN PARACRYSTALS FROM NORMAL AND DYSTROPHIC AVIAN MUSCLE [J].

MCGOWAN, EB ;

SHAFIQ, SA ;

STRACHER, A .

EXPERIMENTAL NEUROLOGY, 1977, 57 (03) :1054-1058

← 1 2 →