COMPARISON OF SALIVA AND BLOOD FOR HUMAN-IMMUNODEFICIENCY-VIRUS PREVALENCE TESTING

被引:83
作者
MAJOR, CJ
READ, SE
COATES, RA
FRANCIS, A
MCLAUGHLIN, BJ
MILLSON, M
SHEPHERD, F
FANNING, M
CALZAVARA, L
MACFADDEN, D
JOHNSON, JK
OSHAUGHNESSY, MV
机构
[1] UNIV TORONTO,FAC MED,DEPT PREVENT MED & BIOSTAT,TORONTO M5S 1A8,ONTARIO,CANADA
[2] UNIV TORONTO,DEPT MED,TORONTO M5S 1A8,ONTARIO,CANADA
[3] UNIV TORONTO,DEPT PEDIAT,TORONTO M5S 1A8,ONTARIO,CANADA
[4] UNIV TORONTO,DEPT MICROBIOL,TORONTO M5S 1A8,ONTARIO,CANADA
[5] HOSP SICK CHILDREN,TORONTO M5G 1X8,ONTARIO,CANADA
[6] HLTH & WELF CANADA,FED CTR AIDS,OTTAWA K1A 0L2,ONTARIO,CANADA
[7] ONTARIO MINIST HLTH,LAB SERV BRANCH,TORONTO M5W 1R5,ONTARIO,CANADA
关键词
D O I
10.1093/infdis/163.4.699
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Testing saliva for the detection of human immunodeficiency virus (HIV) antibodies has many potential advantages for epidemiologic surveillance. A commercial ELISA kit and a standardized in-house immunoblot (IB) system were slightly modified to enhance antibody detection in saliva. Frozen saliva specimens from Toronto Sexual Contact Study participants (including sequential saliva specimens collected during seroconversion) were tested as were fresh saliva samples collected from a population of street-based intravenous drug users (IVDUs). HIV antibody results on saliva were compared with HIV serostatus determined by ELISA and IB on serum or dried blood spots. The overall sensitivity was 98.3% (117/119) for the kit and 99.2% (118/119) for IB; the specificity was 100% (429/429). In the IVDU population, compliance in the voluntary submission of specimens increased from 69% agreeing to provide blood samples to 89% agreeing to provide blood, saliva, or both. Saliva specimens can be easily collected under difficult field conditions with minimal training and provide a valuable alternative to testing blood for HIV-seroprevalence studies.
引用
收藏
页码:699 / 702
页数:4
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