THE COEXISTENCE OF ADENOSINE-A1 AND ADENOSINE-A2 RECEPTORS IN GUINEA-PIG AORTA

被引：50

作者：

STOGGALL, SM

SHAW, JS

机构：

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 190卷 / 03期

关键词：

Adenosine; Adenosine receptors; Aorta (guinea-pig);

D O I：

10.1016/0014-2999(90)94197-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of adenosine, 5'-(N-ethyl)carboxamidoadenosine (NECA), 2-chloroadenosine (2-CA), No-cyclohexyladenosine (CHA) and N6(R-2-phenylisopropyl)-adenosine (R-PIA) on the tone of phenylephrine-constricted guinea-pig isolated aorta have been examined. For aortic relaxation the analogues exhibited the following rank order of potency: NECA > adenosine > 2-CA > R-PIA > CHA. This is consistent with previous reports that relaxation of this tissue is mediated by the adenosine A2 receptor. An unexpected finding was that R-PIA, 2-CA and CHA all induced contractions at concentrations lower than were required for relaxation, giving a biphasic dose-response curve. Neither NECA nor adenosine contracted the aorta. This is consistent with activation of vascular A1 receptors. An A1-selective concentration of the antagonist l,3-dipropyl-8-cyclopentyl xanthine abolished the contraction elicited by R-PIA in the guinea-pig aorta. This further suggests that the contraction is mediated by a1 receptors. © 1990.

引用

页码：329 / 335

页数：7

共 28 条

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