PHOSPHORUS YLIDE CHEMISTRY INVESTIGATED FOR DIHYDROTACHYSTEROL(2) METABOLITE SIDE-CHAIN SYNTHESIS - THE WITTIG APPROACH

被引：10

作者：

HANEKAMP, JC ^{[1
]}

ROOKHUIZEN, RB ^{[1
]}

BOS, HJT ^{[1
]}

BRANDSMA, L ^{[1
]}

机构：

[1] UNIV HOSP UTRECHT,DEPT INTERNAL MED,3584 CX UTRECHT,NETHERLANDS

来源：

TETRAHEDRON | 1992年 / 48卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(01)90124-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The behaviour of the gamma-oxido ylide of R-(3-hydroxy-2,3-dimethylbutyl)triphenylphosphonium iodide 4, to be used in the 25-hydroxylated DHT2 side-chain synthesis, was studied. The synthesis of the chiral phosponium salt 4 was done in an overall yield of 73%. Condensation of the ylide with benzaldehyde afforded the E olefin 11 in a 70% yield; no Z isomer was detected. Furthermore, some other useful phosphonium salts were synthesised.

引用

页码：5151 / 5162

页数：12

共 26 条

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