COCAINE CONDITIONED PLACE PREFERENCE IS ATTENUATED BY CHRONIC BUPRENORPHINE TREATMENT

被引：40

作者：

KOSTEN, TA ^{[1
]}

MARBY, DW ^{[1
]}

NESTLER, EJ ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, DEPT PSYCHIAT, MOLEC PSYCHIAT LAB, NEW HAVEN, CT 06519 USA

来源：

LIFE SCIENCES | 1991年 / 49卷 / 24期

关键词：

D O I：

10.1016/0024-3205(91)90490-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Previous research shows that buprenorphine (BUP), a mixed opioid agonist-antagonist, reduces cocaine use in humans and suppresses cocaine self-administration in monkeys. The present study found that BUP reduces cocaine's ability to condition a place preference in rats. Compared to vehicle treated rats, rats treated with BUP 2 times/day for 2 weeks spent significantly less time in the cocaine conditioned place compared to their respective saline trained controls. No conditioned place preference was shown for BUP alone. These results further implicate a role for the opioid system in cocaine use and stress the importance of differentiating chronic vs. acute opioid effects.

引用

页码：PL201 / PL206

页数：6

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