PAF-ACETHER AND ACETYLHYDROLASE IN STOOL OF PATIENTS WITH CROHNS-DISEASE

被引:52
作者
DENIZOT, Y
CHAUSSADE, S
NATHAN, N
COLOMBEL, JF
BOSSANT, MJ
CHEROUKI, N
BENVENISTE, J
COUTURIER, D
机构
[1] HOP COCHIN,SERV HEPATOGASTROENTEROL,27 RUE FAUBOURG ST JACQUES,F-75674 PARIS 14,FRANCE
[2] INSERM,U200,F-92140 CLAMART,FRANCE
[3] HOP HURIEZ,SERV HEPATOGASTROENTEROL,F-59037 LILLE,FRANCE
[4] NIAAA,DICBR,CLIN STUDIES LAB,BETHESDA,MD 20892
关键词
ACETYLHYDROLASE; CROHNS DISEASE; PAF-ACETHER; STOOL;
D O I
10.1007/BF01307739
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
PAF-acether (PAF) is a phospholipid mediator with potent biological effects on the digestive tract. We report the presence of PAF in stool of patients with active Crohn's disease (39.1 +/- 13.5 ng/g of stool, mean +/- SEM, N = 19) and its absence in patients with irritable bowel syndrome with diarrhea and diarrhea with malabsorption. Fecal PAF acetylhydrolase activity was higher (P < 0.04) in patients with Crohn's disease as compared to patients with irritable bowel syndrome with diarrhea and diarrhea with malabsorption. We also report a solid-phase extraction of fecal PAF using silica minicolumns, which yielded results highly correlated with those obtained with a high-performance liquid chromatography method (r = 0.86, P < 0.001, N = 16). These findings may allow us to implicate PAF in the onset and perpetuation of digestive tract inflammatory symptoms observed during Crohn's disease. They would warrant to investigate the influence of various therapeutic agents, including PAF antagonists, on fecal PAF levels during inflammatory digestive ailments.
引用
收藏
页码:432 / 437
页数:6
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