HIGH-MOLECULAR-WEIGHT POLYOXYETHYLENE AS AN ADDITIVE IN OPHTHALMIC SOLUTIONS

被引：4

作者：

DIMITROVA, E

BOGDANOVA, S

MINKOV, E

MANOLOVA, N

RASCHKOV, I

KOLEVA, M

MIHAILOVA, S

机构：

[1] FAC PHARM SOFIA,2 DUNAV ST,BU-1000 SOFIA,BULGARIA

[2] BULGARIAN ACAD SCI,INST POLYMERS,BU-1113 SOFIA,BULGARIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 93卷 / 1-3期

关键词：

HIGH-MOLECULAR WEIGHT POLYOXYETHYLENE; INDOMETHACIN; OPHTHALMIC SOLUTION; VISCOSITY; STABILITY; IN-VITRO DIFFUSION;

D O I：

10.1016/0378-5173(93)90160-H

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

High-molecular weight polyoxyethylene (POE) was evaluated for potential use as an additive in ophthalmic solutions of indomethacin. The basic drug model was formulated on the basis of hydrotropic and micellar interactions. The influence of POE on the solution viscosity and stability, as well as on in vitro diffusion of indomethacin through an artificial lipid membrane, was comparatively studied with other hydrophilic polymers. It was established that POE shows advantages over hydroxypropylmethylcellulose and polyvinyl alcohol and can be used as a polymeric additive in ophthalmic aqueous solutions of indomethacin.

引用

页码：21 / 26

页数：6

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