ACETOXYDEHYDROAUSTIN, A NEW BIOACTIVE COMPOUND, AND RELATED COMPOUND NEOAUSTIN FROM PENICILLIUM SP MG-11

被引:52
作者
HAYASHI, H [1 ]
MUKAIHARA, M [1 ]
MURAO, S [1 ]
ARAI, M [1 ]
LEE, AY [1 ]
CLARDY, J [1 ]
机构
[1] CORNELL UNIV, DEPT CHEM, ITHACA, NY 14853 USA
关键词
D O I
10.1271/bbb.58.334
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Compounds from a soil isolate of Penicillium sp. MG-11 showed remarkable convulsive activity against silkworms. Activity-based fractionation of an acetone extract of the fermentation products resulted in the isolation of four compounds. One was identified as verruculogen, which was an active principle. Another compound, acetoxydehydroaustin, was new and was structurally characterized by spectral data and a single-crystal X-ray analysis. The two other compounds were identified as dehydroaustin and austin on the basis of the spectral data. Although the latter three compounds were not active themselves, they enhanced the convulsive activity of verruculogen in a silkworm bioassay. Three additional compounds with no identifiable activity were also isolated. Two of them were identified as austinol and dehydroaustinol, and the third was determined to be a new related compound named neoaustin by an X-ray analysis of crystals.
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页码:334 / 338
页数:5
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