HUMAN GLUCOSE PHOSPHATE ISOMERASE - EXON MAPPING AND GENE STRUCTURE

被引：26

作者：

XU, WM ^{[1
]}

LEE, P ^{[1
]}

BEUTLER, E ^{[1
]}

机构：

[1] SCRIPPS RES INST, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA

来源：

GENOMICS | 1995年 / 29卷 / 03期

关键词：

D O I：

10.1006/geno.1995.9944

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structure of the gene for human glucose phosphate isomerase (GPI) has been determined. Three GPI clones were isolated from a human genomic library by using a full-length GPI cDNA probe and were characterized. Oligonucleotides based on the known cDNA sequence were used as primers in amplification and sequence analyses. This led to the identification of the exon-intron junctions. By this approach, 18 exons and 17 introns have been identified. The exons range in size from 44 to 431 nucleotides. The intronic sequences surrounding the exons provide useful information for the identification of mutations that give rise to human GPI deficiency associated with chronic hemolytic anemia. (C) 1995 Academic Press, Inc.

引用

页码：732 / 739

页数：8

共 13 条

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