NUTRITIONAL MANIPULATIONS AND TUMOR-GROWTH .1. EFFECTS OF STARVATION

被引：26

作者：

GOODGAME, JT ^{[1
]}

LOWRY, SF ^{[1
]}

REILLY, JJ ^{[1
]}

JONES, DC ^{[1
]}

BRENNAN, MF ^{[1
]}

机构：

[1] NCI,SURG BRANCH,SURG METAB SECT,BETHESDA,MD 20014

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1979年 / 32卷 / 11期

关键词：

D O I：

10.1093/ajcn/32.11.2277

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effects of starvation on tumor and host growth were studied in growing male Fischer rats bearing methylcholanthrene-induced sarcomas. Tumor growth was evaluated by changes in weight, volume, and incorporation of tritiated methyl thymidine into tumor DNA, (dpm/μg DNA). Host growth was followed by changes in total body weight, and dpm/μg liver DNA. All periods of starvation (24 to 96 hr) caused significant decreases in host body and carcass weight and dpm/μg liver DNA. Changes in tumor weight and tumor volume in fed and starved animals were equal. Tumor dpm/μg DNA in starved animals decreased (P<0.005) relative to fed controls at 48, 72, and 96 hr starvation intervals. Starvation allows continued tumor growth while host wasting occurs, and is accompanied by increased tumor dpm/μg DNA in this system.

引用

页码：2277 / 2284

页数：8

共 23 条

[1]

Addis T, 1936, J BIOL CHEM, V115, P117

[2]

Addis T, 1936, J BIOL CHEM, V115, P111

[3]

BARVICK L, 1954, J NATL CANCER I, V15, P177

[4]

BASERGA R, 1968, NORMAL MALIGNANT CEL, P118

[5]

BENNETT LL, 1956, FED PROC, V15, P218

[6]

COPELAND EM, 1975, AM J SURG, V129, P167, DOI 10.1016/0002-9610(75)90293-7

[7]

DANNEBERG PB, 1958, CANCER RES, V18, P329

[8] AN IMPROVED DIPHENYLAMINE METHOD FOR ESTIMATION OF DEOXYRIBONUCLEIC ACID [J].

GILES, KW ;

MYERS, A .

NATURE, 1965, 206 (4979) :93-&

[9]

GRANT JP, 1974, J SURG RES, V16, P552

[10] RATE OF RENEWAL OF RIBO AND DESOXYRIBO NUCLEIC ACIDS [J].

HAMMARSTEN, E ;

HEVESY, G .

ACTA PHYSIOLOGICA SCANDINAVICA, 1946, 11 (04) :335-343

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