GRANULOMATOUS HEPATITIS DUE TO COMBINATION OF AMOXICILLIN AND CLAVULANIC ACID

We report the case of a patient with amoxicillinclavulanic acid-induced hepatitis with histologic multiple granulomas. This type of lesion broadens the spectrum of liver injury due to this drug combination, mainly represented by a benign cholestatic syndrome. The association of granulomas and eosinophilia favor an immunoallergic mechanism. As penicillin derivatives and amoxicillin alone are known to induce such types of lesions, the amoxicillin component, with or with-out a potentiating effect of clavulanic acid, might have a major role. © 1992 Plenum Publishing Corporation.