DETERMINATION OF SULTOPRIDE AND TIAPRIDE IN SERUM BY GAS-CHROMATOGRAPHY USING A SURFACE-IONIZATION DETECTOR

被引：14

作者：

KAMIZONO, A

INOTSUME, N

MIYAMOTO, K

UEDA, K

MIYAKAWA, T

ARIMOTO, H

NAKANO, M

机构：

[1] KUMAMOTO UNIV HOSP, DEPT PHARMACEUT SERV, 1-1-1 HONJO, KUMAMOTO 860, JAPAN

[2] KUMAMOTO UNIV, SCH MED, DEPT PSYCHIAT, KUMAMOTO 860, JAPAN

[3] SHIMADZU CO LTD, DEPT ANALYT APPLICAT, NAKAGYO, KYOTO 604, JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 567卷 / 01期

关键词：

D O I：

10.1016/0378-4347(91)80315-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive and selective method has been developed for the determination of sultopride and tiapride in serum using gas chromatography with a surface ionisation detector. No interfering peaks from endogenous substances were observed. The method showed good reproducibility and accuracy, and the standard curve was linear up to 2-mu-g/ml with a correlation coefficient of 0.999. This method is applicable to pharmacokinetic studies and therapeutic drug monitoring of sultopride and tiapride.

引用

页码：113 / 120

页数：8

共 10 条

[1] QUANTITATIVE-ANALYSIS OF SULPIRIDE AND SULTOPRIDE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR PHARMACOKINETIC STUDIES [J].