A NEW APPROACH TO THE RAPID-DETERMINATION OF PROTEIN SIDE-CHAIN CONFORMATIONS

被引：283

作者：

TUFFERY, P ^{[1
]}

ETCHEBEST, C ^{[1
]}

HAZOUT, S ^{[1
]}

LAVERY, R ^{[1
]}

机构：

[1] INST BIOL MOLEC,BIOCHIM THEOR LAB,CNRS,URA 77,F-75005 PARIS,FRANCE

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 1991年 / 8卷 / 06期

关键词：

D O I：

10.1080/07391102.1991.10507882

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two efficient algorithms have been developed which allow amino acid side chain conformations to be optimized rapidly for a given peptide backbone conformation. Both these approaches are based on the assumption that each side chain can be represented by a small number of rotameric states. These states have been obtained by a dynamic cluster analysis of a large data base of known crystallographic structures. Successful applications of these algorithms to the prediction of known protein conformations are presented.

引用

页码：1267 / 1289

页数：23

共 14 条

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