AN INTESTINAL XENOGRAFT MODEL FOR CRYPTOSPORIDIUM-PARVUM INFECTION

被引：12

作者：

THULIN, JD

KUHLENSCHMIDT, MS

ROLSMA, MD

CURRENT, WL

GELBERG, HB

机构：

[1] UNIV ILLINOIS,COLL VET MED,DEPT VET PATHOBIOL,URBANA,IL 61801

[2] ELI LILLY & CO,LILLY RES LAB,LILLY CORP CTR,INDIANAPOLIS,IN 46285

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 01期

关键词：

D O I：

10.1128/IAI.62.1.329-331.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Paired segments of near-term fetal rabbit small intestine were transplanted subcutaneously into athymic nude mice. At 5 weeks postsurgery, the xenografts were inoculated intraluminally with Cryptosporidium parvum sporozoites. Parasites rapidly and reliably infected the xenograft mucosal epithelium. Lesions typical of cryptosporidiosis were readily apparent by light microscopy and scanning and transmission electron microscopy. Xenografts are well suited to the study of the early events of C. parvum infection and are of potential value in the evaluation of anticryptosporidial chemotherapeutic agents.

引用

页码：329 / 331

页数：3

共 18 条

[1] CRYPTOSPORIDIOSIS IN GUINEA-PIGS - AN ANIMAL-MODEL [J].