A MODEL OF THE STIMULATION OF A NERVE-FIBER BY ELECTROMAGNETIC INDUCTION

被引：258

作者：

ROTH, BJ

BASSER, PJ

机构：

[1] Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 1990年 / 37卷 / 06期

关键词：

Action Potential - Electromagnetic Induction - Hodgkin-Huxley Cable Model - Maxwell's Equations - Nerve Stimulation - Transmembrane Potential;

D O I：

10.1109/10.55662

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A model is presented to explain the physics of nerve stimulation by electromagnetic induction. Maxwell's equations predict the induced electric field distribution that is produced when a capacitor is discharged through a stimulating coil. A nonlinear Hodgkin-Huxley cable model describes the response of the nerve fiber to this induced electric field. Once the coil's position, orientation, and shape are given and the resistance, capacitance, and initial voltage of the stimulating circuit are specified, this model predicts the resulting transmembrane potential of the fiber as a function of distance and time. It is shown that the nerve fiber is stimulated by the gradient of the component of the induced electric field that is parallel to the fiber, which hyperpolarizes or depolarizes the membrane and may stimulate an action potential. Finally, it predicts complicated dynamics such as action potential annihilation and dispersion. © 1990 IEEE

引用

页码：588 / 597

页数：10

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