CLONAL DELETION OF V-BETA 14-BEARING T-CELLS IN MICE TRANSGENIC FOR MAMMARY-TUMOR VIRUS

被引：314

作者：

ACHAORBEA, H

SHAKHOV, AN

SCARPELLINO, L

KOLB, E

MULLER, V

VESSAZSHAW, A

FUCHS, R

BLOCHLINGER, K

ROLLINI, P

BILLOTTE, J

SARAFIDOU, M

MACDONALD, HR

DIGGELMANN, H

机构：

[1] UNIV ZURICH,INST IMMUNOL & VIROL,CH-8051 ZURICH,SWITZERLAND

[2] SWISS INST EXPTL CANC RES,CH-1066 EPALINGES,SWITZERLAND

来源：

NATURE | 1991年 / 350卷 / 6315期

关键词：

D O I：

10.1038/350207a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V-beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V-beta-14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.

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页码：207 / 211

页数：5

相关论文

共 51 条

[1] ANALYSIS OF MLSC GENETICS - A NOVEL INSTANCE OF GENETIC REDUNDANCY [J].

ABE, R ;

FOOPHILLIPS, M ;

HODES, RJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1059-1073

[2] MURINE T-CELL RECEPTOR MUTANTS WITH DELETIONS OF BETA-CHAIN VARIABLE REGION GENES [J].

BEHLKE, MA ;

CHOU, HS ;

HUPPI, K ;

LOH, DY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (03) :767-771

[3] STRONG HISTOCOMPATIBILITY AND CELL-MEDIATED CYTO-TOXIC EFFECTS OF A SINGLE MLS DIFFERENCE DEMONSTRATED USING A NEW CONGENIC MOUSE STRAIN [J].

BERUMEN, L ;

HALLEPANNENKO, O ;

FESTENSTEIN, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1983, 13 (04) :292-300

[4] THE MHC MOLECULE I-E IS NECESSARY BUT NOT SUFFICIENT FOR THE CLONAL DELETION OF V-BETA-11-BEARING T-CELLS [J].

BILL, J ;

KANAGAWA, O ;

WOODLAND, DL ;

PALMER, E .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (04) :1405-1419

[5]

BLOCHLINGER K, 1986, THESIS U LAUSANNE

[6] CLONED MOUSE MAMMARY-TUMOR VIRUS-DNA IS BIOLOGICALLY-ACTIVE IN TRANSFECTED MOUSE CELLS AND ITS EXPRESSION IS STIMULATED BY GLUCOCORTICOID HORMONES [J].

BUETTI, E ;

DIGGELMANN, H .

CELL, 1981, 23 (02) :335-345

[7] GENES ENCODING LIGANDS FOR DELETION OF V-BETA-11 T-CELLS COSEGREGATE WITH MAMMARY-TUMOR VIRUS GENOMES [J].

DYSON, PJ ;

KNIGHT, AM ;

FAIRCHILD, S ;

SIMPSON, E ;

TOMONARI, K .

NATURE, 1991, 349 (6309) :531-532

[8]

EICHER EM, 1990, GENETICS, V125, P431

[9] THE REGION OF MOUSE MAMMARY-TUMOR VIRUS-DNA CONTAINING THE LONG TERMINAL REPEAT INCLUDES A LONG CODING SEQUENCE AND SIGNALS FOR HORMONALLY REGULATED TRANSCRIPTION [J].

FASEL, N ;

PEARSON, K ;

BUETTI, E ;

DIGGELMANN, H .

EMBO JOURNAL, 1982, 1 (01) :3-7

[10]

FESTENSTEIN H, 1973, TRANSPLANT REV-DENMA, V15, P62

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