OSMOTIC AND ACTIVITY-COEFFICIENTS OF AQUEOUS BILE-SALT SOLUTIONS AT 25-DEGREES-C, 37-DEGREES-C, AND 45-DEGREES-C

被引:21
作者
CARPENTER, P [1 ]
LINDENBAUM, S [1 ]
机构
[1] UNIV KANSAS,DEPT PHARMACEUT CHEM,MCCOLLUM LABS,LAWRENCE,KS 66045
关键词
activity coefficients; bile salts; Osmotic coefficients; sodium chenodeoxycholate; sodium cholate; sodium deoxycholate; sodium glycochenodeoxycholate; sodium glycocholate; sodium glycodeoxycholate; sodium taurocholate; sodium taurodeoxycholate;
D O I
10.1007/BF00646787
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Osmotic coefficients measured by vapor pressure osmometry are reported for aqueous bile salt solutions at 25, 37, and 45°C. Solute activities decrease rapidly with increasing concentration due to premicellar association and micelle formation. In all cases, activities of the dihydroxy bile salts are lower than those of the trihydroxy bile salts. Osmotic coefficients and activity coefficients increase with increasing temperature. It is suggested that hydrophobic forces contribute substantially to the stability of primary bile salt aggregates and micelles. © 1979 Plenum Publishing Corporation.
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页码:347 / 357
页数:11
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