DESIGN AND PERFORMANCE OF AN ELECTROSPRAY IONIZATION SOURCE FOR A DOUBLY-FOCUSING MAGNETIC-SECTOR MASS-SPECTROMETER

被引:37
作者
GALLAGHER, RT [1 ]
CHAPMAN, JR [1 ]
MANN, M [1 ]
机构
[1] KRATOS ANALYT,BARTON DOCK RD,MANCHESTER M31 2LD,ENGLAND
关键词
D O I
10.1002/rcm.1290041004
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Design considerations for an electrospray ionization source on a double‐focusing magnetic sector mass spectrometer are discussed. A source with two additional pumping stages before the source housing has been constructed. High sensitivity for multiply charged ions from high molecular weight proteins up to 66 kDa is demonstrated with this source. Copyright © 1990 John Wiley & Sons Limited
引用
收藏
页码:369 / 372
页数:4
相关论文
共 11 条
  • [1] Meng C.K., Mann M., Fenn J.B., Zeit. Phys. D, 10, (1988)
  • [2] Fenn J.B., Mann M., Meng C.K., Wong S.F., Whitehouse C.M., Science, 246, (1989)
  • [3] Fenn J.B., Mann M., Meng C.K., Wong S.F., Mass Spectrom. Revs, 9, (1990)
  • [4] Smith R.D., Loo J.A., Edmonds C.G., Barinaga C.J., Udseth H.R., Anal. Chem., 62, (1990)
  • [5] Alexandrov M.L., Gall L.N., Krasnov V.N., Nikolaev V.I., Pavlenko V.A., Shkurov V.A., Dokl. Akad. Nauk SSR, 277, (1984)
  • [6] Allen M.H., Lewis I.A.S., Electrospray on magnetic instruments, Rapid Communications in Mass Spectrometry, 3, (1989)
  • [7] Meng C.K., McEwen C.N., Larsen B.S., Rapid Commun. Mass Spectrom., 4, (1989)
  • [8] Meng C.K., McEwen C.N., Larsen B.S., Rapid Commun. Mass Spectrom., 4, (1989)
  • [9] Mann M., Wong S.F., Fenn J.B., Ion Formation from Organic Solids, IFOS V, (1990)
  • [10] Whitehouse C.M., Dreyer R.N., Yamashita M., Fenn J.B., Anal. Chem., 57, (1985)