WIDESPREAD DISTRIBUTION OF FREE D-ASPARTATE IN RAT PERIPHERY

被引:96
作者
HASHIMOTO, A
NISHIKAWA, T
OKA, T
HAYASHI, T
TAKAHASHI, K
机构
[1] RES DEV CORP JAPAN,CELL & INFORMAT PRECURSORY RES EMBRYON SCI & TECHNOL GRP,CHIYODA KU,TOKYO 100,JAPAN
[2] NATL CTR HOSP MENTAL NERVOUS & MUSCULAR DISORDER,NCNP,KODAIRA,TOKYO 187,JAPAN
[3] GRELAN PHARMACEUTICAL CO LTD,SETAGAYA KU,TOKYO 154,JAPAN
关键词
D-ASPARTATE; D-ASPARTATE OXIDASE; D-SERINE; D-ENANTIOMER; RAT PERIPHERY;
D O I
10.1016/0014-5793(93)80286-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have identified and quantified free D-aspartate in adult rat peripheral organs using ps chromatographic-mass spectrometric and high-performance liquid chromatographic techniques. The level of free D-aspartate was highest in the adrenal, testis, spleen and pituitary, followed by the thymus, lung, ovary, placenta, pancreas and heart, and below the detection limit in the kidney, liver, brain, muscle and serum. These data provide the first evidence that a high level Of free D-aspartate widely occurs in the adult rat periphery and suggest that the D-amino acid may be an endogenous substrate for D-aspartate oxidase.
引用
收藏
页码:4 / 8
页数:5
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